Research Focus 1:
Improve diagnostics, prevention, and treatment of the stiff heart through basic, translational and clinical studies.
Carlson Group:
- Andreas Romaine: Understanding the functional impact and origin of cardiac fibrosis in the ageing rat heart
- Lucie Pejšková: Chicken Health: Preventing wooden breast by identifying and editing regulators of severe chicken myopathy
Cataliotti Group:
- Use of vibrational spectroscopy as a sensitive technique for early diagnosis of heart diseases
- Identification of panels of microRNAs as diagnostic and prognostic tools
- ProANP31-65 as a novel therapeutic candidate for treatment of chronic heart failure
- Theranostic application of small RNA molecules in heart failure with preserved ejection fraction
- Identification of small molecules as positive allosteric modulators of Guanylyl Cyclase-A
- Development of novel delivery strategies to directly target heart tissue
Christensen Group:
- Andreas Romaine: Mechanisms of fibrosis development in aging rats
- Athiramol Sasi: The role of versican in cardiac fibrosis
- Chloe Rixon: The role of lumican in hypertrophic cardiomyopathy
- Francesca Lockwood: The role of syndecan in cardiac pressure overload
- Maria Vistnes: Inhibition of the enzyme ADAMTS4 in cardiac diseases with fibrosis
Stokke Group:
- Kristine Andreassen: Can exercise training prevent disease development in individuals genetically predisposed for hypertrophic cardiomyopathy?
- Ahmed: Pacemaker therapy for hypertrophic obstructive cardiomyopathy
- Simon Girmai Berger: Cardiovascular Function in Connective Tissue Disease
Research Focus 2:
Reveal integrative mechanisms for heart failure and arrhythmias, as a basis for understanding and treatment of electromechanical dysfunction in patients.
Carlson Group:
- Ilde Rugolo: Novel treatment of cardiac dysfunction and arrhythmia in at-risk patients
- Pim Wanichawan: Junctophilin-2 anchors and functionally regulate the Na2+/Ca2+ exchanger in cardiac dyads
- Cathrine Carlson: AKAP18δ anchors and functionally regulate calcineurin at SERCA2
Louch Group:
- Michael Frisk: Understanding the molecular basis for non-compaction syndrome
- Jia Li: Non-homogeneous sarcomere strain as a novel mechanism of HFrEF
- Harmonie Perdreau-Dahl: Mechanisms controlling cardiomyocyte membrane maintenance in health and HFrEF
- Xin Shen: Disassembly of the Sarcoplasmic Reticulum promotes HFrEF progression
- Martin Laasmaa: Triggering of the heartbeat by LTCC-RyR crosstalk in health and HFrEF
- Christopher Le: Spreading of dysfunction during HFrEF development
- Victoria Becker: Mechanisms for cardiomyopathy syndrome in salmon»
- Anna Bergan-Dahl: Revealing CaMKII movement in the RyR microdomain in health and HFrEF
- Magnhild Sekse Erdal: Targeting titin to restore cardiomyocyte function in heart failure
- Adelle Basson: Cardiomyocyte ageing and parallels to the failing heart
- Pia Skovholt Halvorsen: Understanding early-onset cardiac dysfunction in farmed salmon
Stokke Group:
- Marie Synnøve Hansen: Calcium dependent arrhythmia mechanisms in CPVT and ischemia-reperfusion
- Tristan Hellstrand: Quantification of SERCA-RyR balance in calcium-dependent arrhythmias
- Stine Aagaard-Nilsen: Predictors of outcome of catheter ablation for premature ventricular complexes
- Petter Mikal Johansen Skar: Relationship between heart rate and premature ventricular complexes
- Ahmed: Utility of cardiac MRI in evaluation of patients with premature ventricular complexes
Research Focus 3:
Reveal cellular signaling pathways responsible for cardiac mechanosensing, and remodeling as a basis for future therapy.
Carlson Group:
- Thea Parsberg Støle: Mechanisms behind development of familial cardiomyopathy
- Thea Parsberg Støle: Sex differences in syndecan-4 signaling
Louch Group:
- Ornella Manfra: Workload dependent assembly of dyads in cardiomyocytes
- Marianne Ruud: Regulation of cardiomyocyte t-tubule structure by preload and afterload