Research Focus 1:
Improve diagnostics, prevention, and treatment of the stiff heart through basic, translational and clinical studies.
Carlson Group:
- Andreas Romaine: Understanding the functional impact and origin of cardiac fibrosis in the ageing rat heart
- Lucie Pejšková: Chicken Health: Preventing wooden breast by identifying and editing regulators of severe chicken myopathy
Cataliotti Group:
- Sara Stefani: Use of vibrational spectroscopy as a sensitive technique for early diagnosis of heart diseases
- Reza Parvan: Theranostic application of small RNA molecules in heart failure with preserved ejection fraction
- Henriette Andresen: Identification of small molecules as positive allosteric modulators of Guanylyl Cyclase-A
- Reza Parvan: Development of novel delivery strategies to directly target heart tissue
- Alessandro Cataliotti: ProANP31-65 as a novel therapeutic candidate for treatment of chronic heart failure
Sjaastad Group:
- Emil Knut Espe: Investigating the right side of the failing hear
- Ida Marie Hauge Iversen: NODDY: Novel Imaging Biomarker targeting Diastolic Dysfunction.
- Lili Zhang: Optimizing fibrosis imaging in CMR.
- Trine Hjørnevik, Ivar Sjaastad: FibroPET, imaging cardiac fibrosis with PET.
- Kasper Klausen: Myocardial stiffness – the missing link in heart failure (elastography).
- Bård Andre Bendiksen: Structure-function relationship in heart failure.
- Theis Christian Tønnessen: Why does rheumatoid arthritis cause heart failure.
- Henriette Marstein: Organ involvement in Juvenile Dermatomyositis.
- Markus Borge Harbo: SYNCME: Targeting cardiac remodeling through myocardial dyssynchrony.
- Henrik Dukefoss: RELAX: Targeting the stiff heart through cardiac magnetic resonance imaging.
- Mohammed Almashhadani: Myocardial work in aortic stenosis.
- Yasmin Donnabel Reyes: CENS, Cardiovascular remodelling in living kidney donors with reduced glomerular filtration rate.
Stokke Group:
- Kristine Andreassen: Can exercise training prevent disease development in individuals genetically predisposed for hypertrophic cardiomyopathy?
- Ahmed: Pacemaker therapy for hypertrophic obstructive cardiomyopathy
- Simon Girmai Berger: Cardiovascular Function in Connective Tissue Disease
- Athiramol Sasi: The role of versican in cardiac fibrosis
- Chloe Rixon: The role of lumican in hypertrophic cardiomyopathy
Research Focus 2:
Reveal integrative mechanisms for heart failure and arrhythmias, as a basis for understanding and treatment of electromechanical dysfunction in patients.
Carlson Group:
- Ilde Rugolo: Novel treatment of cardiac dysfunction and arrhythmia in at-risk patients
- Pim Wanichawan: Junctophilin-2 anchors and functionally regulate the Na2+/Ca2+ exchanger in cardiac dyads
- Cathrine Carlson: AKAP18δ anchors and functionally regulate calcineurin at SERCA2
Louch Group:
- Michael Frisk: Understanding the molecular basis for non-compaction syndrome
- Jia Li: Non-homogeneous sarcomere strain as a novel mechanism of HFrEF
- Harmonie Perdreau-Dahl: Mechanisms controlling cardiomyocyte membrane maintenance in health and HFrEF
- Xin Shen: Disassembly of the Sarcoplasmic Reticulum promotes HFrEF progression
- Martin Laasmaa: Triggering of the heartbeat by LTCC-RyR crosstalk in health and HFrEF
- Christopher Le: Spreading of dysfunction during HFrEF development
- Victoria Becker: Mechanisms for cardiomyopathy syndrome in salmon»
- Anna Bergan-Dahl: Revealing CaMKII movement in the RyR microdomain in health and HFrEF
- Magnhild Sekse Erdal: Targeting titin to restore cardiomyocyte function in heart failure
- Adelle Basson: Cardiomyocyte ageing and parallels to the failing heart
- Pia Skovholt Halvorsen: Understanding early-onset cardiac dysfunction in farmed salmon
Stokke Group:
- Marie Synnøve Hansen: Calcium dependent arrhythmia mechanisms in CPVT and ischemia-reperfusion
- Tristan Hellstrand: Quantification of SERCA-RyR balance in calcium-dependent arrhythmias
- Stine Aagaard-Nilsen: Predictors of outcome of catheter ablation for premature ventricular complexes
- Petter Mikal Johansen Skar: Relationship between heart rate and premature ventricular complexes
- Ahmed: Utility of cardiac MRI in evaluation of patients with premature ventricular complexes
Research Focus 3:
Reveal cellular signaling pathways responsible for cardiac mechanosensing, and remodeling as a basis for future therapy.
Carlson Group:
- Thea Parsberg Støle: Mechanisms behind development of familial cardiomyopathy
- Thea Parsberg Støle: Sex differences in syndecan-4 signaling
Louch Group:
- Ornella Manfra: Workload dependent assembly of dyads in cardiomyocytes
- Marianne Ruud: Regulation of cardiomyocyte t-tubule structure by preload and afterload