Cardiomyocyte function in health and disease

Louch group

Our research is aimed at understanding abnormal cellular calcium handling, with focus on the structures and proteins that control calcium cycling.

Cardiac function is tightly controlled by the contraction and relaxation of these cells; processes which are in turn reliant on carefully controlled calcium homeostasis. Indeed, cardiac dysfunction during diseases such as heart failure and atrial fibrillation can often be traced to abnormal cellular calcium handling.

Our research is aimed at understanding these abnormalities, with focus on the structures and proteins that control calcium cycling. How are these structures and proteins put together during development, and what causes them to disassemble during disease? What is the consequence of such alterations? To examine these questions, we combine molecular biology and electrophysiology techniques with advanced 3D imaging (super-resolution, confocal, and electron microscopy).

Ultimately, we strive to mechanistically link subcellular structure and calcium handling to whole-heart function, and to reverse dysfunction during disease for the benefit of patients.

Group leader William (Bill) Louch is a Professor of Medicine and Head of the Core Facility for Advanced Light Microscopy. He currently holds a Consolidator Grant from the European Research Council which was initiated in 2015. His group’s research is focused on understanding the structure and function cardiac muscle cells.

Group members

Anna Bergan Dahl

Doctoral Research Fellow

Christopher Le

Researcher without PhD

Harmonie Perdreau-Dahl

Postdoctoral fellow

Ingunn Elise Setterberg

Researcher without PhD

Jia Li

Postdoctoral fellow

Kiarash Tazmini

Doctoral Research Fellow

Martin Laasmaa

Postdoctoral fellow

Ornella Manfra

Postdoctoral fellow

Terje Kolstad

Researcher without PhD

Victoria Becker

Doctoral Research Fellow

Xin Shen

Postdoctoral fellow

Yufeng Hou

Postdoctoral fellow

Latest publications

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Yamakawa S, Wu D, Dasgupta M, Pedamallu H, Gupta B, Modi R, Mufti M, O'Callaghan C, Frisk M, Louch WE, Arora R, Shiferaw Y, Burrell A, Ryan J, Nelson L, Chow M, Shah SJ, Aistrup G, Zhou J, Marszalec W, Wasserstrom JA (2021)
Role of t-tubule remodeling on mechanisms of abnormal calcium release during heart failure development in canine ventricle
Am J Physiol Heart Circ Physiol, 320 (4), H1658-H1669
PubMed 33635163 DOI 10.1152/ajpheart.00946.2020
Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
PubMed 33509397 DOI 10.1016/j.jacc.2020.11.044
Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK (2021)
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
PubMed 33569394 DOI 10.3389/fcvm.2020.623922
Frisk M, Hoyland M, Zhang LL, Vindas MA, Overli O, Johansen IB (2020)
Intensive smolt production is associated with deviating cardiac morphology in Atlantic salmon (Salmo salar L.)
Aquaculture, 529, 735615
DOI 10.1016/j.aquaculture.2020.735615
Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR (2020)
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Mol Ther, 29 (1), 409
PubMed 33296664 DOI 10.1016/j.ymthe.2020.11.015
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