Cardiomyocyte function in health and disease

Louch group

Our research is aimed at understanding abnormal cellular calcium handling, with focus on the structures and proteins that control calcium cycling.

Cardiac function is tightly controlled by the contraction and relaxation of these cells; processes which are in turn reliant on carefully controlled calcium homeostasis. Indeed, cardiac dysfunction during diseases such as heart failure and atrial fibrillation can often be traced to abnormal cellular calcium handling.

Our research is aimed at understanding these abnormalities, with focus on the structures and proteins that control calcium cycling. How are these structures and proteins put together during development, and what causes them to disassemble during disease? What is the consequence of such alterations? To examine these questions, we combine molecular biology and electrophysiology techniques with advanced 3D imaging (super-resolution, confocal, and electron microscopy).

Ultimately, we strive to mechanistically link subcellular structure and calcium handling to whole-heart function, and to reverse dysfunction during disease for the benefit of patients.

Group leader William (Bill) Louch is a Professor of Medicine and Head of the Core Facility for Advanced Light Microscopy. He currently holds a Consolidator Grant from the European Research Council which was initiated in 2015. His group’s research is focused on understanding the structure and function cardiac muscle cells.

Group Leader

William (Bill) Louch

Group Leader & Professor

Group members

Anna Bergan Dahl

Doctoral Research Fellow

Christopher Le

Researcher without PhD

Harmonie Perdreau-Dahl

Postdoctoral fellow

Jia Li

Postdoctoral fellow

Martin Laasmaa

Postdoctoral fellow

Michael Frisk

Postdoctoral fellow

Ornella Manfra

Postdoctoral fellow

Per Kristian Lunde

Senior Researcher

Simona Kavaliauskiene

Postdoctoral fellow

Terje Kolstad

Researcher without PhD

Victoria Becker

Doctoral Research Fellow

Xin Shen

Postdoctoral fellow

Yufeng Hou

Postdoctoral fellow

Latest publications

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Zhou J, Singh N, Monnier C, Marszalec W, Gao L, Jin J, Frisk M, Louch WE, Verma S, Krishnamurthy P, Nico E, Mulla M, Aistrup GL, Kishore R, Wasserstrom JA (2021)
Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure
Front Physiol, 12, 782767
PubMed 35002765 DOI 10.3389/fphys.2021.782767
Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
PubMed 34814703 DOI 10.1161/CIRCRESAHA.120.317976
Dibb KM, Louch WE, Trafford AW (2021)
Cardiac Transverse Tubules in Physiology and Heart Failure
Annu Rev Physiol
PubMed 34780259 DOI 10.1146/annurev-physiol-061121-040148
Setterberg IE, Le C, Frisk M, Perdreau-Dahl H, Li J, Louch WE (2021)
Corrigendum: The Physiology and Pathophysiology of T-Tubules in the Heart
Front Physiol, 12, 790227
PubMed 34764889 DOI 10.3389/fphys.2021.790227
Edwards AG, Mørk H, Stokke MK, Lipsett DB, Sjaastad I, Richard S, Sejersted OM, Louch WE (2021)
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
Front Physiol, 12, 744730
PubMed 34712150 DOI 10.3389/fphys.2021.744730
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