Louch group:
Cardiomyocyte function in health and disease

Our research is aimed at understanding abnormal cellular calcium handling, with focus on the structures and proteins that control calcium cycling.

Cardiac function is tightly controlled by the contraction and relaxation of these cells; processes which are in turn reliant on carefully controlled calcium homeostasis. Indeed, cardiac dysfunction during diseases such as heart failure and atrial fibrillation can often be traced to abnormal cellular calcium handling.

Our research is aimed at understanding these abnormalities, with focus on the structures and proteins that control calcium cycling. How are these structures and proteins put together during development, and what causes them to disassemble during disease? What is the consequence of such alterations? To examine these questions, we combine molecular biology and electrophysiology techniques with advanced 3D imaging (super-resolution, confocal, and electron microscopy).

Ultimately, we strive to mechanistically link subcellular structure and calcium handling to whole-heart function, and to reverse dysfunction during disease for the benefit of patients.

Group leader William (Bill) Louch is a Professor of Medicine and Head of the Core Facility for Advanced Light Microscopy. He has recently held a Consolidator Grant from the European Research Council, and currently holds a Researcher Grant from the Norwegian Research Council. His group’s research is focused on understanding the structure and function cardiac muscle cells.

Group Leader

William (Bill) Louch

Group Leader & Professor

Group members

Adelle Basson

Doctoral Research Fellow

Anna Bergan Dahl

Doctoral Research Fellow

Christopher Le

Doctoral Research Fellow

Harmonie Perdreau-Dahl

Postdoctoral fellow

Jia Li

Postdoctoral fellow

Magnhild Sekse Erdal

Doctoral Research Fellow

Martin Laasmaa

Postdoctoral fellow

Michael Frisk

Postdoctoral fellow

Nishani Mabotuwana

Postdoctoral fellow

Ornella Manfra

Postdoctoral fellow

Pia Skovholt Halvorsen

Doctoral Research Fellow

Victoria Becker

Doctoral Research Fellow & Safety representative (VO)

Xin Shen

Postdoctoral fellow

Associated members

Yufeng Hou

Postdoctoral fellow

Latest publications

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Zhang X, Wu Y, Smith C, Louch WE, Morotti S, Dobrev D, Grandi E, Ni H (2024)
Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling
bioRxiv
PubMed 38496584 DOI 10.1101/2024.03.04.583217
Sun B, Vindas MA, Kavaliauskiene S, Bjørgen H, Koppang EO, Wisløff H, Frisk M, Lund H, Johansen IB (2024)
Persistent immune responses in the heart determine the outcome of cardiomyopathy syndrome in Atlantic salmon (Salmo salar)
Fish Shellfish Immunol, 147, 109404
PubMed 38325590 DOI 10.1016/j.fsi.2024.109404
Lunde PK, Manfra O, Støle TP, Lunde M, Martinsen M, Carlson CR, Louch WE (2023)
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 12 (19)
PubMed 37830576 DOI 10.3390/cells12192358
Laasmaa M, Branovets J, Stolova J, Shen X, Rätsepso T, Balodis MJ, Grahv C, Hendrikson E, Louch WE, Birkedal R, Vendelin M (2023)
Cardiomyocytes from female compared to male mice have larger ryanodine receptor clusters and higher calcium spark frequency
J Physiol, 601 (18), 4033-4052
PubMed 37561554 DOI 10.1113/JP284515
Li J, Sundnes J, Hou Y, Laasmaa M, Ruud M, Unger A, Kolstad TR, Frisk M, Norseng PA, Yang L, Setterberg IE, Alves ES, Kalakoutis M, Sejersted OM, Lanner JT, Linke WA, Lunde IG, de Tombe PP, Louch WE (2023)
Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte
Circ Res, 133 (3), 255-270
PubMed 37401464 DOI 10.1161/CIRCRESAHA.123.322588
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