Louch group: Cardiomyocyte function in health and disease

Louch group

Our research is aimed at understanding abnormal cellular calcium handling, with focus on the structures and proteins that control calcium cycling.

Cardiac function is tightly controlled by the contraction and relaxation of these cells; processes which are in turn reliant on carefully controlled calcium homeostasis. Indeed, cardiac dysfunction during diseases such as heart failure and atrial fibrillation can often be traced to abnormal cellular calcium handling.

Our research is aimed at understanding these abnormalities, with focus on the structures and proteins that control calcium cycling. How are these structures and proteins put together during development, and what causes them to disassemble during disease? What is the consequence of such alterations? To examine these questions, we combine molecular biology and electrophysiology techniques with advanced 3D imaging (super-resolution, confocal, and electron microscopy).

Ultimately, we strive to mechanistically link subcellular structure and calcium handling to whole-heart function, and to reverse dysfunction during disease for the benefit of patients.

Group leader William (Bill) Louch is a Professor of Medicine and Head of the Core Facility for Advanced Light Microscopy. He currently holds a Consolidator Grant from the European Research Council which was initiated in 2015. His group’s research is focused on understanding the structure and function cardiac muscle cells.

Group Leader

William (Bill) Louch

Group Leader & Professor

Group members

Adelle Basson

Doctoral Research Fellow

Anna Bergan Dahl

Doctoral Research Fellow

Christopher Le

Researcher without PhD

Harmonie Perdreau-Dahl

Postdoctoral fellow

Jia Li

Postdoctoral fellow

Martin Laasmaa

Postdoctoral fellow

Michael Frisk

Postdoctoral fellow

Ornella Manfra

Postdoctoral fellow

Per Kristian Lunde

Senior Researcher

Simona Kavaliauskiene

Postdoctoral fellow

Victoria Becker

Doctoral Research Fellow

Xin Shen

Postdoctoral fellow

Yufeng Hou

Postdoctoral fellow

Latest publications

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Hernández Mesa M, van den Brink J, Louch WE, McCabe KJ, Rangamani P (2022)
Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks
PLoS Comput Biol, 18 (6), e1010126
PubMed 35666763 DOI 10.1371/journal.pcbi.1010126
De Genst E, Foo KS, Xiao Y, Rohner E, de Vries E, Sohlmér J, Witman N, Hidalgo A, Kolstad TRS, Louch WE, Pehrsson S, Park A, Ikeda Y, Li X, Mayr LM, Wickson K, Jennbacken K, Hansson K, Fritsche-Danielson R, Hunt J, Chien KR (2022)
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Nat Commun, 13 (1), 3018
PubMed 35641497 DOI 10.1038/s41467-022-29703-9
Louch WE (2022)
A TRP to the emergency room: Understanding arrhythmia in the ageing heart
Cardiovasc Res, 118 (4), 932-933
PubMed 35225325 DOI 10.1093/cvr/cvac017
Louch WE, Perdreau-Dahl H, Edwards AG (2022)
Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?
Front Physiol, 13, 834211
PubMed 35356084 DOI 10.3389/fphys.2022.834211
Sommese LM, Racioppi MF, Shen X, Orlowski A, Valverde CA, Louch WE, Vila Petroff M, Gonano LA (2022)
Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation
Pflugers Arch, 474 (6), 625-636
PubMed 35235009 DOI 10.1007/s00424-022-02678-8
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Group news

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Doctoral Thesis

PhD Defence: Terje Ricardo Selnes Kolstad

13/05/2022
General

dSTORM: In a blink of a molecule

12/05/2022
Seminars and conferences

IEMR – Project meeting,
Peter Kohl

06/05/2022
Publications

Riding the Tube: Cardiac Transverse Tubules in Physiology and Heart Failure

03/03/2022
People

People at IEMR: Michael Frisk

25/10/2021
Seminars and conferences

IEMR – Project meeting,
Dr. Susan Howlett

07/10/2021