Email: xin.shen@medisin.uio.no
Funding
– Research Council of Norway
Academic interests
Exploring functional and structural differences of the cardiac dyad in health and disease by combining the usage of confocal and super-resolution microscopy (dSTORM, Electron Miscroscopy).
Research area
- Advanced light microscopy
- Arrhythmias
- Cardiomyocyte signaling
- Cardiomyopathies
- Excitation contraction coupling
- Heart failure
Latest publications
view all >Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, Christensen G, Carlson CR (2022)
The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
PubMed 36092718 DOI 10.3389/fcell.2022.908126
The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
PubMed 36092718 DOI 10.3389/fcell.2022.908126
Shen X, van den Brink J, Bergan-Dahl A, Kolstad TR, Norden ES, Hou Y, Laasmaa M, Aguilar-Sanchez Y, Quick AP, Espe EKS, Sjaastad I, Wehrens XHT, Edwards AG, Soeller C, Louch WE (2022)
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Elife, 11
PubMed 35913125 DOI 10.7554/eLife.77725
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Elife, 11
PubMed 35913125 DOI 10.7554/eLife.77725
Sommese LM, Racioppi MF, Shen X, Orlowski A, Valverde CA, Louch WE, Vila Petroff M, Gonano LA (2022)
Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation
Pflugers Arch, 474 (6), 625-636
PubMed 35235009 DOI 10.1007/s00424-022-02678-8
Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation
Pflugers Arch, 474 (6), 625-636
PubMed 35235009 DOI 10.1007/s00424-022-02678-8
Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
PubMed 34814703 DOI 10.1161/CIRCRESAHA.120.317976
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
PubMed 34814703 DOI 10.1161/CIRCRESAHA.120.317976
Hou Y, Bai J, Shen X, de Langen O, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C, Crossman DJ (2021)
Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart
Front Physiol, 12, 724372
PubMed 34690801 DOI 10.3389/fphys.2021.724372
Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart
Front Physiol, 12, 724372
PubMed 34690801 DOI 10.3389/fphys.2021.724372