Stokke group: Translational arrhythmology and electrophysiology

We aim to understand processes that lead to cardiac disease due to pathological electrophysiology, especially arrhythmias. Our goal is that this insight will lead to improved diagnostics and therapy for patients with cardiac disease.

Our translational research team work to unravel fundamental principles of cardiac electrophysiology, in order to provide a better understanding and management of clinical conditions caused by abnormal electrical activity in the heart. We use observations from patients as the outset for our laboratory experiments, and test key findings in large animal models and clinical situations.

 

We want to be able to predict and prevent triggers of arrhythmic events, and to provide a basis for the use of exercise for electrophysiological remodeling in a safe manner. We especially focus on the role of calcium handling by cardiac proteins associated with the sarcoplasmic reticulum, such as RyR2, SERCA2 and CaMKII. To better understand the role of these proteins, we use rodent models of heart failure, CPVT, HCM and ischemia-reperfusion.

 

We combine clinical observations and interventions with molecular biology, cellular electrophysiology, Langendorff-perfused hearts and in vivo characterization by echocardiography, MRI and telemetric ECG recording. We also expose rodent models to exercise training by voluntary running in resistance-controlled running wheels and treadmills. As part of this strategy, we collaborate closely with other research groups with expertise on basic research methods, clinical electrophysiology, cardiac imaging and cardiogenetics. This provides us the opportunity to understand biological processes involved in pathological electrophysiology on a molecular, cellular, organ and organism level.

Group leader Mathis Korseberg Stokke is Professor I at UiO and Consultant Cardiologist at the Arrhythmia Unit, Department of Cardiology, Oslo University Hospital Rikshospitalet. He is also Deputy Director of NORHEART – The Norwegian PhD School of Heart Research. He leads a research group with researchers of different academic backgrounds and specific know-how, from nanotechnology and molecular biology to clinical training in cardiology. The group also collaborates closely with clinicians and researchers at Oslo University Hospital, and with international collaborators in the US, Germany and UK.

 

Group Leader

Mathis Korseberg Stokke

Head of Department & Group Leader & Professor & Senior Consultant

Group members

Athiramol Sasi

Doctoral Research Fellow

Chloe Rixon

Doctoral Research Fellow

Petter Mikal Johansen Skar

Medical Research Curriculum Student

Semra Öztemel Sari

Doctoral Research Fellow

Simon Girmai Berger

Doctoral Research Fellow

Stine Aagaard-Nilsen

Medical Research Curriculum Student

Tristan Hellstrand

Medical Research Curriculum Student

Associated members

Kristine Mørk Kindberg

Doctoral Research Fellow

Pernille Borch

Medical Research Curriculum Student

Tariq Nazir Ahmed

Doctoral Research Fellow

Latest publications

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Ruud M, Frisk M, Melleby AO, Norseng PA, Mohamed BA, Li J, Aronsen JM, Setterberg IE, Jakubiczka J, van Hout I, Coffey S, Shen X, Nygård S, Lunde IG, Tønnessen T, Jones PP, Sjaastad I, Gullestad L, Toischer K, Dahl CP, Christensen G, Louch WE (2024)
Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation
J Physiol
PubMed 38686538 DOI 10.1113/JP284566
Espe E, Stokke MK (2024)
Editorial for "MRI Assessment of Myocardial Deformation for Risk Stratification of Major Arrhythmic Events in Patients with Non-Ischemic Cardiomyopathy Eligible for Primary Prevention Implantable Cardioverter Defibrillators"
J Magn Reson Imaging
PubMed 38358060 DOI 10.1002/jmri.29300
Mjølstad OC, Radtke M, Brodtkorb E, Edvardsen F, Brede WR, Aamo TO, Jacobsen D, Stokke MK, Helland A (2023)
Recurrent malignant ventricular arrhythmias and paresthesia-a mystery revealed as aconitine poisoning: a case report
J Med Case Rep, 17 (1), 554
PubMed 38129927 DOI 10.1186/s13256-023-04304-2
Sasi A, Romaine A, Erusappan PM, Melleby AO, Hasic A, Dahl CP, Broch K, Almaas VM, Puertas RD, Roderick HL, Lunde IG, Sjaastad I, Vistnes M, Christensen G (2023)
Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development
Matrix Biol Plus, 19-20, 100135
PubMed 38076279 DOI 10.1016/j.mbplus.2023.100135
Haugsten Hansen M, Sadredini M, Hasic A, Eriksen M, Stokke MK (2023)
Myocardial oxidative stress is increased in early reperfusion, but systemic antioxidative therapy does not prevent ischemia-reperfusion arrhythmias in pigs
Front Cardiovasc Med, 10, 1223496
PubMed 37823177 DOI 10.3389/fcvm.2023.1223496
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