Image: Profile picture of Ornella Manfra

Ornella Manfra

Postdoctoral fellow

Louch group

Email: ornella.manfra@studmed.uio.no

Funding
Research Council of Norway Researcher Grant, Mobility Grant 2018.
Research project in collaboration with Oregon Health & Science University (OHSU), Portland, USA and Professor Kent L. Thornburg as chair of Cardiovascular Research in the Knight Cardiovascular Institute.

Academic interests

• Examining the structure of cardiac dyads and function of cardiac muscle cells in health and disease.

• Determine how cardiac dyads are assembled during development, with an examination of their nanostructure structure and regulation by mechanical load, in fetal sheep heart.

List all publications

Research area

  • Advanced light microscopy
  • Excitation contraction coupling
  • Heart failure
  • Imaging

Latest publications

view all >
Lunde PK, Manfra O, Støle TP, Lunde M, Martinsen M, Carlson CR, Louch WE (2023)
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 12 (19)
PubMed 37830576 DOI 10.3390/cells12192358
Manfra O, Louey S, Jonker SS, Perdreau-Dahl H, Frisk M, Giraud GD, Thornburg KL, Louch WE (2023)
Augmenting workload drives T-tubule assembly in developing cardiomyocytes
J Physiol
PubMed 37128962 DOI 10.1113/JP284538
Hou Y, Laasmaa M, Li J, Shen X, Manfra O, Norden ES, Le C, Zhang L, Sjaastad I, Jones PP, Soeller C, Louch WE (2023)
Live-cell photo-activated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Nat Cardiovasc Res, 2 (3), 251-267
PubMed 38803363 DOI 10.1038/s44161-022-00199-2
Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
PubMed 33509397 DOI 10.1016/j.jacc.2020.11.044
Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE (2020)
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
PubMed 32070187 DOI 10.1161/CIRCRESAHA.119.315641
view all >