Email: ornella.manfra@studmed.uio.no
Funding
Research Council of Norway Researcher Grant, Mobility Grant 2018.
Research project in collaboration with Oregon Health & Science University (OHSU), Portland, USA and Professor Kent L. Thornburg as chair of Cardiovascular Research in the Knight Cardiovascular Institute.
Academic interests
• Examining the structure of cardiac dyads and function of cardiac muscle cells in health and disease.
• Determine how cardiac dyads are assembled during development, with an examination of their nanostructure structure and regulation by mechanical load, in fetal sheep heart.
Research area
- Advanced light microscopy
- Excitation contraction coupling
- Heart failure
- Imaging
Latest publications
view all >Manfra O, Louey S, Jonker SS, Perdreau-Dahl H, Frisk M, Giraud GD, Thornburg KL, Louch WE (2023)
Augmenting workload drives T-tubule assembly in developing cardiomyocytes
J Physiol
PubMed 37128962 DOI 10.1113/JP284538
Augmenting workload drives T-tubule assembly in developing cardiomyocytes
J Physiol
PubMed 37128962 DOI 10.1113/JP284538
Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
PubMed 33509397 DOI 10.1016/j.jacc.2020.11.044
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
PubMed 33509397 DOI 10.1016/j.jacc.2020.11.044
Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE (2020)
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
PubMed 32070187 DOI 10.1161/CIRCRESAHA.119.315641
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
PubMed 32070187 DOI 10.1161/CIRCRESAHA.119.315641
Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Andersen GØ, Sjaastad I, Louch WE (2019)
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
PubMed 30351410 DOI 10.1093/cvr/cvy257
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
PubMed 30351410 DOI 10.1093/cvr/cvy257
Lubelwana Hafver T, Wanichawan P, Manfra O, de Souza GA, Lunde M, Martinsen M, Louch WE, Sejersted OM, Carlson CR (2017)
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
PubMed 28755400 DOI 10.1002/pmic.201600417
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
PubMed 28755400 DOI 10.1002/pmic.201600417