Email: andreas.romaine@medisin.uio.no
Funding
Scientia post-doctoral fellowship & KG Jebsen grant (2021).
Education
Andreas completed his undergraduate education at Imperial College London, gaining a Master’s degree and Bachelor of Science degree in Immunology and Biomedical Research.
He continued his study of integrins, this time in the context of heart disease, completing a PhD in cardiac research at the University of Oslo.
Academic interests
- Studying the activation of cardiac fibroblasts through cell-surface signaling, with a focus on integrin and proteoglycan biology.
- Identification of therapeutic targets of cardiac fibrosis
Research methodologies
- Flow cytometry and cell sorting
- Mass spectrometry
- Advanced light microscopy
Research area
- Cell signaling
- Fibroblast signaling
- Fibrosis
- Heart failure
Latest publications
view all >Romaine A, Melleby AO, Alam J, Lobert VH, Lu N, Lockwood FE, Hasic A, Lunde IG, Sjaastad I, Stenmark H, Herum KM, Gullberg D, Christensen G (2022)
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Am J Physiol Heart Circ Physiol, 322 (6), H1057-H1071
PubMed 35522553 DOI 10.1152/ajpheart.00635.2021
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Am J Physiol Heart Circ Physiol, 322 (6), H1057-H1071
PubMed 35522553 DOI 10.1152/ajpheart.00635.2021
Alam J, Musiime M, Romaine A, Sawant M, Melleby AO, Lu N, Eckes B, Christensen G, Gullberg D (2020)
Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
Matrix Biol Plus, 8, 100045
PubMed 33543038 DOI 10.1016/j.mbplus.2020.100045
Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
Matrix Biol Plus, 8, 100045
PubMed 33543038 DOI 10.1016/j.mbplus.2020.100045
Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
PubMed 32000579 DOI 10.1161/JAHA.119.013518
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
PubMed 32000579 DOI 10.1161/JAHA.119.013518
Mathiesen SB, Lunde M, Aronsen JM, Romaine A, Kaupang A, Martinsen M, de Souza GA, Nyman TA, Sjaastad I, Christensen G, Carlson CR (2019)
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
PubMed 30967474 DOI 10.1074/jbc.RA118.006423
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
PubMed 30967474 DOI 10.1074/jbc.RA118.006423
Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G (2018)
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc Res, 114 (12), 1680-1690
PubMed 29878127 DOI 10.1093/cvr/cvy141
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc Res, 114 (12), 1680-1690
PubMed 29878127 DOI 10.1093/cvr/cvy141