Advanced translational cardiac imaging

Sjaastad group

The aim of our group is to develop new advanced cardiac imaging tools, to exploit these and understand the remodelling process occurring in cardiac diseases, and search for new imaging biomarkers predicting adverse disease outcome.

During cardiac disease, the heart is exposed to various stress factors, such as hypertension, ischemia and infarction. This results in both structural and functional remodelling of the heart. However, the these processes are complex and result in a large variety of phenotypes. Additionally, available imaging techniques have limited capability to identify the details in structural and functional cardiac remodelling. Accordingly, robust imaging biomarkers of cardiac disease progression are lacking.

Over the last years we have explored the potential of tissue phased mapping, a MR technique, to offer high resolution functional imaging of the heart. This technique has the capability to advance cardiac imaging directly by offering new biomarkers of disease entities, but also to facilitate the development of new imaging techniques such as cardiac elastography. We are working to establish elastography as a 3D technique to identify myocardial stiffness, which primarily is a result of fibrosis. We are also using other techniques, such as T1 mapping and diffusion tensor imaging, to investigate myocardial structure. Additionally, we are using mathematical remodelling to integrate our imaging data to understand the underlying pathological processes, and identify new imaging biomarkers of cardiac syndroms, such as diastolic dysfunction.

Our group is translating new concepts and techniques from preclinical use to human imaging. We are running several clinical studies, investigating for instance biomarkers for early detection of fibrosis, 3D parameters of diastolic dysfunction, and effects of various diseases (such as kidney failure) on cardiac function.

The group leader is professor Ivar Sjaastad, which is a cardiologist. Group members have diverse academic background, such as clinical medicine, physics, mathematics, molecular biology and radiology. We are collaborating with leading national research groups in cardiology, radiology, nuclear medicine, cancer medicine, various clinical specialities, physics and mathematics. Also, our international collaborators are at the highest level, located at for instance the Mayo clinic, KU Leuven and University of Chicago.

Group Leader

Ivar Sjaastad

Head of Department & Group Leader & Professor & Senior Consultant

Group members

Bård Andre Bendiksen

Doctoral Research Fellow

Birgit Nomeland Witczak

Doctoral Research Fellow

Emil Espe

Postdoctoral fellow

Gary McGinley

Doctoral Research Fellow

Haelin Kim

Research Technician

Henriette Schermacher Marstein

Doctoral Research Fellow

Henrik Dukefoss

Doctoral Research Fellow

Ida Marie Hauge-Iversen

Researcher without PhD

Kjersti Blom

Doctoral Research Fellow

Lili Zhang

Senior Engineer

Linn Espeland

Research Technician

Lisa Smith

Postdoctoral fellow

Markus Borge Harbo

Medical Research Curriculum Student

Mohammed Almashhadani

Medical Research Curriculum Student

Latest publications

view all >
Witczak BN, Schwartz T, Barth Z, Taraldsrud E, Lund MB, Aaløkken TM, Flatø B, Sjaastad I, Sanner H (2022)
Associations between cardiac and pulmonary involvement in patients with juvenile dermatomyositis-a cross-sectional study
Rheumatol Int
PubMed 34984516 DOI 10.1007/s00296-021-05071-3
Harbo MB, Stokke MK, Sjaastad I, Espe EKS (2022)
One step closer to myocardial physiology: From PV loop analysis to state-of-the-art myocardial imaging
Acta Physiol (Oxf), e13759
PubMed 34978759 DOI 10.1111/apha.13759
Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
PubMed 34814703 DOI 10.1161/CIRCRESAHA.120.317976
Blom KB, Åsberg A, Sjaastad I, Kalleberg KT, Søraas A, Midtvedt K, Birkeland JA (2021)
Kidney Transplant Recipient Behavior During the Early COVID-19 Pandemic: A National Survey Study in Norway
Kidney Med
PubMed 34805967 DOI 10.1016/j.xkme.2021.09.006
Witczak BN, Bollerslev J, Godang K, Schwartz T, Flatø B, Molberg Ø, Sjaastad I, Sanner H (2021)
Body composition in longstanding juvenile dermatomyositis; Associations with disease activity, muscle strength and cardiometabolic measures
Rheumatology (Oxford)
PubMed 34718443 DOI 10.1093/rheumatology/keab805
view all >