Sjaastad group:
Advanced translational cardiac imaging

The aim of our group is to develop new advanced cardiac imaging tools, to exploit these and understand the remodelling process occurring in cardiac diseases, and search for new imaging biomarkers predicting adverse disease outcome.

During cardiac disease, the heart is exposed to various stress factors, such as hypertension, ischemia and infarction. This results in both structural and functional remodelling of the heart. However, the these processes are complex and result in a large variety of phenotypes. Additionally, available imaging techniques have limited capability to identify the details in structural and functional cardiac remodelling. Accordingly, robust imaging biomarkers of cardiac disease progression are lacking.

Over the last years we have explored the potential of tissue phased mapping, a MR technique, to offer high resolution functional imaging of the heart. This technique has the capability to advance cardiac imaging directly by offering new biomarkers of disease entities, but also to facilitate the development of new imaging techniques such as cardiac elastography. We are working to establish elastography as a 3D technique to identify myocardial stiffness, which primarily is a result of fibrosis. We are also using other techniques, such as T1 mapping and diffusion tensor imaging, to investigate myocardial structure. Additionally, we are using mathematical remodelling to integrate our imaging data to understand the underlying pathological processes, and identify new imaging biomarkers of cardiac syndroms, such as diastolic dysfunction.

Our group is translating new concepts and techniques from preclinical use to human imaging. We are running several clinical studies, investigating for instance biomarkers for early detection of fibrosis, 3D parameters of diastolic dysfunction, and effects of various diseases (such as kidney failure) on cardiac function.

The group leader is professor Ivar Sjaastad, which is a cardiologist. Group members have diverse academic background, such as clinical medicine, physics, mathematics, molecular biology and radiology. We are collaborating with leading national research groups in cardiology, radiology, nuclear medicine, cancer medicine, various clinical specialities, physics and mathematics. Also, our international collaborators are at the highest level, located at for instance the Mayo clinic, KU Leuven and University of Chicago.

Group Leader

Ivar Sjaastad

Group Leader & Professor & Senior Consultant

Group members

Bård Andre Bendiksen

Doctoral Research Fellow

Birgit Nomeland Witczak

Doctoral Research Fellow

Emil Espe

Postdoctoral fellow

Haelin Kim

Research Technician

Henriette Schermacher Marstein

Doctoral Research Fellow

Henrik Dukefoss

Doctoral Research Fellow

Ida Marie Hauge-Iversen

Doctoral Research Fellow

Kasper Klausen

Specialist engineer

Kjersti Blom

Doctoral Research Fellow

Lili Zhang

Senior Engineer

Lisa Smith

Postdoctoral fellow

Markus Borge Harbo

Doctoral Research Fellow

Mohammed Almashhadani

Medical Research Curriculum Student

Yasmin Donnabel Reyes

Doctoral Research Fellow

Latest publications

view all >
Espe E, Stokke MK (2024)
Editorial for "MRI Assessment of Myocardial Deformation for Risk Stratification of Major Arrhythmic Events in Patients with Non-Ischemic Cardiomyopathy Eligible for Primary Prevention Implantable Cardioverter Defibrillators"
J Magn Reson Imaging
PubMed 38358060 DOI 10.1002/jmri.29300
Sasi A, Romaine A, Erusappan PM, Melleby AO, Hasic A, Dahl CP, Broch K, Almaas VM, Puertas RD, Roderick HL, Lunde IG, Sjaastad I, Vistnes M, Christensen G (2023)
Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development
Matrix Biol Plus, 19-20, 100135
PubMed 38076279 DOI 10.1016/j.mbplus.2023.100135
Nordén ES, Veras I, Yadav P, Løken K, Dishington H, Thorstensen C, Sjaastad I, Rasmussen H (2023)
Clinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery
Lab Anim, 236772231178417
PubMed 37669442 DOI 10.1177/00236772231178417
Vistnes M, Erusappan PM, Sasi A, Nordén ES, Bergo KK, Romaine A, Lunde IG, Zhang L, Olsen MB, Øgaard J, Carlson CR, Wang CH, Riise J, Dahl CP, Fiane AE, Hauge-Iversen IM, Espe E, Melleby AO, Tønnessen T, Aronsen JM, Sjaastad I, Christensen G (2023)
Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction
Cardiovasc Res, 119 (10), 1915-1927
PubMed 37216909 DOI 10.1093/cvr/cvad078
Blom KB, Birkeland GK, Midtvedt K, Jenssen TG, Reisæter AV, Rollag H, Hartmann A, Sagedal S, Sjaastad I, Tylden G, Njølstad G, Nilsen E, Christensen A, Åsberg A, Birkeland JA (2023)
Cytomegalovirus High-risk Kidney Transplant Recipients Show No Difference in Long-term Outcomes Following Preemptive Versus Prophylactic Management
Transplantation, 107 (8), 1846-1853
PubMed 37211633 DOI 10.1097/TP.0000000000004615
view all >