Peptides used for transport of cargo over the cell membrane can have unwanted effects on calcium handling.
Per Kristian Lunde, Ornella Manfra, Thea Parsberg Støle, Marianne Lunde, Marita Martinsen, Cathrine Rein Carlson and William E. Louch
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Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
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Oslo University Hospital prize for outstanding research paper
Oslo University Hospital awards prizes every six months to six outstanding research articles featuring key authors from the hospital. On December 8th, the prizes were awarded for articles published in the first half of 2023. One of the winners was Harmonie Perdreau-Dahl, from the Louch Group at IEMR.
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People at IEMR: Jia Li
Jia Li is a postdoctoral fellow at IEMR, working with cardiomyocyte signaling and excitation contraction coupling. Her recent article shows how the contractile units of cardiac muscle cells function, and how they become dysfunctional during disease.
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How stretch brings harmony to the heart: a new article in Circulation Research
Li J, Sundnes J, Hou Y, Laasmaa M, Ruud M, Unger A, Kolstad TR, Frisk M, Norseng PA, Yang L, Setterberg IE, Alves ES, Kalakoutis M, Sejersted OM, Lanner JT, Linke WA, Lunde IG, de Tombe PP, Louch WE
Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte
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Understanding how 3 proteins work together to allow the maturation of heart muscle cells during development
Harmonie Perdreau-Dahl, David B. Lipsett, Michael Frisk, Fatemeh Kermani, Cathrine R. Carlson, Andreas Brech, Xin Shen, Anna Bergan-Dahl, Yufeng Hou, Tomi Tuomainen, Pasi Tavi, Peter P. Jones, Marianne Lunde, J. Andrew Wasserstrom, Jocelyn Laporte, Nina D. Ullrich, Geir Christensen, J. Preben Morth, William E. Louch
BIN1, myotubularin, and dynamin-2 coordinate t-tubule growth in cardiomyocytes
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Understanding how heart muscle cells are put together during development
Ornella Manfra, Samantha Louey, Sonnet S. Jonker, Harmonie Perdreau-Dahl, Michael Frisk, George D Giraud, Kent L. Thornburg, and William E. Louch
Augmenting Workload Drives T-tubule Assembly in Developing Cardiomyocytes
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A new article in Nature Cardiovascular Research shows how calcium release channels work together to trigger the heartbeat
Yufeng Hou, Martin Laasmaa, Jia Li, Xin Shen, Ornella Manfra, Einar S Nordén, Christopher Le, Lili Zhang, Ivar Sjaastad, Peter P Jones, Christian Soeller, William E Louch
Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
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IEMR – Project meeting,
Denis Reis de Assis
21. April 2023
“Estrogen rescues glucose metabolism but not calcium homeostasis in iPSC-derived neural progenitor cells from patients with schizophrenia”
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IEMR – Project meeting,
Pete Jones
10. March 2023
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Tubulator: automated analysis of cardiomyocyte organelles and proteins in 3D
Frisk M, Norseng PA, Stenersen Espe EK, Louch WE
Tubulator: an automated approach to analysis of t-tubule and dyadic organization in cardiomyocytes
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