William (Bill) Louch

Group Leader & Professor

Louch group

Email: w.e.louch@medisin.uio.no
Phone: +47 230 16793

Education
2001 PhD Pharmacology, Dalhousie University, Halifax, Canada
1997 BSc Chemistry/Neuroscience, Dalhousie University, Halifax, Canada

Positions
2018- Secretary General, The Scandinavian Physiological Society
2015- Professor of Medicine, IEMR
2015- Treasurer, Federation of European Physiological Sciences (FEPS),
2013- Head, Core Facility for Advanced Light Microscopy, OUH

Funding
– European Research Council Consolidator Grant
– Research Council of Norway Researcher Grant, Mobility Grant
– National Association for Public Health (2 postdoctoral grants)
– South-Eastern Norway Regional Health Authority (PhD student, postdoc grants)

Awards, committees and memberships
2020- Head of Organizing Committee –“Europhysiology” meeting in Copenhagen, 2022.
2018- Organizer, Cardiac Physiology Satellite Meeting, Europhysiology, London, UK.
2017- Partner, KG Jebsen Center for Cardiac Research
2015 Digitalis Pupurea Award for Research Excellence, University of Oslo Medical Faculty

Research area

Advanced light microscopy
Arrhythmias
Diastolic dysfunction
Electrophysiology
Excitation contraction coupling
Heart failure
Imaging

Latest publications

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Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Søvik Eken O, Veras I, Thi-Huynh NT, Børstad M, Marshall S, Shen X, Louch WE, Louise Robinson E, Cleveland JC, Ambardekar AV, Schwisow JA, Jonas E, Calejo AIC, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM (2023)
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation
PubMed 36876489 DOI 10.1161/CIRCULATIONAHA.121.054168

Gamage TH, Grabmayr H, Horvath F, Fahrner M, Misceo D, Louch WE, Gunnes G, Pullisaar H, Reseland JE, Lyngstadaas SP, Holmgren A, Amundsen SS, Rathner P, Cerofolini L, Ravera E, Krobath H, Luchinat C, Renger T, Müller N, Romanin C, Frengen E (2023)
A single amino acid deletion in the ER Ca²⁺ sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation
Sci Signal, 16 (771), eadd0509
PubMed 36749824 DOI 10.1126/scisignal.add0509

Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG (2022)
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
PubMed 36539599 DOI 10.1038/s42003-022-04361-1

Louch WE, Ullrich ND, Navedo MF, Macquaide N (2022)
Editorial: Nanodomain regulation of muscle physiology and alterations in disease
Front Physiol, 13, 1092304
PubMed 36523550 DOI 10.3389/fphys.2022.1092304

Rixon C, Andreassen K, Shen X, Erusappan PM, Almaas VM, Palmero S, Dahl CP, Ueland T, Sjaastad I, Louch WE, Stokke MK, Tønnessen T, Christensen G, Lunde IG (2022)
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail
PubMed 36444917 DOI 10.1002/ehf2.14234

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