News archive

Towards new treatments for cardiac fibrosis: ADAMTS4 inhibition in heart failure

Maria Vistnes, Pugazendhi Murugan Erusappan, Athiramol Sasi, Einar Sjaastad Nordén, Kaja Bergo, Andreas Romaine, Ida Gjervold Lunde, Lili Zhang, Maria Belland Olsen, Jonas Øgaard, Cathrine Rein Carlson, Christian Hjorth Wang, Jon Riise, Christen Peder Dahl, Arnt Eltvedt Fiane, Ida Marie Hauge-Iversen, Emil Espe, Arne Olav Melleby, Theis Tønnessen, Jan Magnus Aronsen, Ivar Sjaastad, Geir Christensen

—

Inhibition of the extracellular enzyme ADAMTS4 prevents cardiac fibrosis and dysfunction

Beneficial effects of exercise in genotype positive HCM mice

Kristine Andreassen, Chloe Rixon, Marie H Hansen, Ida Marie Hauge-Iversen, Lili Zhang, Mani Sadredini, Pugazendhi M Erusappan, Ivar Sjaastad, Geir Christensen, Kristina H Haugaa, Thor Edvardsen, Ida G Lunde, Mathis K Stokke

Beneficial effects of exercise initiated prior to development of hypertrophic cardiomyopathy in genotype positive mice

—

Understanding how heart muscle cells are put together during development

Ornella Manfra, Samantha Louey, Sonnet S. Jonker, Harmonie Perdreau-Dahl, Michael Frisk, George D Giraud, Kent L. Thornburg, and William E. Louch

Augmenting Workload Drives T-tubule Assembly in Developing Cardiomyocytes

—

Cardiac dysfunction in mixed connective tissue disease: More evidence for why cardiologists should care about rheumatic disease

Simon Girmai Berger, Birgit Nomeland Witczak, Silje Reiseter, Thomas Schwartz, Helena Andersson, Siri Opsahl Hetlevik, Kristin Schjander Berntsen, Helga Sanner, Vibke Lilleby, Ragnar Gunnarsson, Øyvind Molberg, Ivar Sjaastad, Mathis Korseberg Stokke

Cardiac dysfunction in mixed connective tissue disease: a nationwide observational study

—

A new article in Nature Cardiovascular Research shows how calcium release channels work together to trigger the heartbeat

Yufeng Hou, Martin Laasmaa, Jia Li, Xin Shen, Ornella Manfra, Einar S Nordén, Christopher Le, Lili Zhang, Ivar Sjaastad, Peter P Jones, Christian Soeller, William E Louch

Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes

—

A novel understanding of the matrix protein lumican in hypertrophic cardiomyopathy (HCM)

Rixon C, Andreassen K, Shen X, Erusappan PM, Almaas VM, Palmero S, Dahl CP, Ueland T, Sjaastad I, Louch WE, Stokke MK, Tønnessen T, Christensen G, Lunde IG

Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy

—

The extracellular matrix protein ‘ADAMTSL3’ is crucial for preserving cardiac structure and function in heart failure

Karoline B Rypdal, A Olav Melleby, Emma L Robinson, Jia Li, Sheryl Palmero, Deborah E Seifert, Daniel Martin, Catelyn Clark, Begoña López, Kristine Andreassen, Christen P Dahl, Ivar Sjaastad, Theis Tønnessen, Mathis K Stokke, William E Louch, Arantxa González, Stephane Heymans, Geir Christensen, Suneel S Apte, Ida G Lunde

ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload

—

New insights into reperfusion arrhythmias

CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKIIδ at methionines 281/282 is not a determining factor.

Calcineurin-NFAT dynamics corresponds to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement

Ida G. Lunde, Biljana Skrbic, Ivar Sjaastad, Geir Christensen, Cathrine R. Carlson, Theis Tønnessen

—

MicroRNAs Diagnostic Performance in Heart Failure: a Systematic Review and Meta-Analysis

Reza Parvan, Milad Hosseinpour, Yousef Moradi, Yvan Devaux, Alessandro Cataliotti, Gustavo J.J. da Silva

—