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Two sides of a coin: New perspective on antiarrhythmic treatment

CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation

Mani Sadredini, Marie Haugsten Hansen, Michael Frisk, William E. Louch, Stephan E. Lehnart, Ivar Sjaastad, and Mathis Korseberg Stokke

The multifunctional enzyme calcium/calmodulin-dependent kinase II (CaMKII) is a promising target for future antiarrhythmic therapy. However, antiarrhythmic therapy sometimes have pro-arrhythmic side-effects. PhD student Mani Sadredini and colleagues from the Stokke group have studied if targeting CaMKII can have such unwanted pro-arrhythmic effects.

Together with Professor Stephan Lehnart from the University of Göttingen, Germany, they used a mouse model of the rare genetic disease catecholaminergic polymorphic ventricular tachycardia (CPVT) to show that CaMKII inhibition indeed limits one mechanism for calcium-dependent arrhythmias, but at the same time increases the tendency for another mechanism, called calcium alternans. In the CPVT mice, calcium alternans was still within the normal range, indicating that inhibition of CaMKII is safe in CPVT. However, the study illustrates that both calcium-dependent arrhythmia mechanisms must be considered when CaMKII inhibition is used to prevent arrhythmias in other conditions, i.e. both sides of the coin should be remembered.

 

Read the article in American Journal of Physiology – Heart and Circulatory Physiology

 doi: 10.1152/ajpheart.00011.2021

Mani Sadredini

Postdoctoral fellow

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Mathis Korseberg Stokke

Head of Department & Group Leader & Professor & Senior Consultant

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Institute for Experimental Medical Research

Oslo University Hospital, Ullevål

PB 4956 Nydalen

NO-0424 Oslo

Norway

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