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PhD Defence: Tore Kristian Danielsen

Tore Kristian Danielsen from the Stokke group has defended the thesis “Arrhythmia mechanisms and effects of exercise training in CPVT and post-infarction heart failure” for the degree of PhD (Philosophiae Doctor).

November 10, 2022

Adjudication committee

  • First opponent: Professor Godfrey Smith, Institute of Cardiovascular and Medical science, University of Glasgow, Scotland
  • Second opponent: Professor Ellen Aasum, Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Science– The Arctic University of Norway, Tromsø
  • Third member and chair of the evaluation committee: Professor Torbjørn Omland, Institute of Clinical Medicine, Akershus University Hospital and University of Oslo

Chair of the defence: Professor Em. Ingebjørg Seljeflot, University of Oslo

Principal Supervisor: Professor Mathis Korseberg Stokke, University of Oslo

Summary

Regular physical activity protect against cardiovascular disease. However, exercise can provoke fatal heart rhythm disturbances in some conditions. Patients with heart failure have increased risk of heart rhythm disturbances. On a cellular level, heart failure share some alterations with the rare disease catecholaminergic polymorphic ventricular tachycardia (CPVT). Both diseases have altered ryanodine receptor (RyR) function. Calcium release by RyR in the cardiomyocytes controls electric activity and contraction of the heart. Release of calcium in the diastole due to RyR dysfunction increases the propensity for arrhythmias, cardiac arrest and sudden cardiac death. Previous research has indicated that exercise can modify RyR function.

In this doctoral thesis, Tore Kristian Danielsen and coworkers have investigated the mechanisms behind disrupted calcium handling in CPVT and heart failure and the effect of exercise on this mechanism for arrhythmias.

The first paper confirmed that stress-stimulation of the heart is the most important stimuli for arrhythmia development in CPVT, but also that increased heart rate might contribute independently through potentiated release of calcium.

In paper two and three, we investigate the anti-arrhythmic effect of exercise in CPVT and heart failure, respectively. We found that exercise attenuated abnormal calcium release in cardiomyocytes, which might decrease the propensity for arrhythmias.

 

 

Tore Kristian Danielsen

Doctoral Research Fellow

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Institute for Experimental Medical Research

Oslo University Hospital, Ullevål

PB 4956 Nydalen

NO-0424 Oslo

Norway

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