News archive

The extracellular matrix protein ‘ADAMTSL3’ is crucial for preserving cardiac structure and function in heart failure

Karoline B Rypdal, A Olav Melleby, Emma L Robinson, Jia Li, Sheryl Palmero, Deborah E Seifert, Daniel Martin, Catelyn Clark, Begoña López, Kristine Andreassen, Christen P Dahl, Ivar Sjaastad, Theis Tønnessen, Mathis K Stokke, William E Louch, Arantxa González, Stephane Heymans, Geir Christensen, Suneel S Apte, Ida G Lunde

ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload

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New insights into reperfusion arrhythmias

CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKIIδ at methionines 281/282 is not a determining factor.

Calcineurin-NFAT dynamics corresponds to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement

Ida G. Lunde, Biljana Skrbic, Ivar Sjaastad, Geir Christensen, Cathrine R. Carlson, Theis Tønnessen

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MicroRNAs Diagnostic Performance in Heart Failure: a Systematic Review and Meta-Analysis

Reza Parvan, Milad Hosseinpour, Yousef Moradi, Yvan Devaux, Alessandro Cataliotti, Gustavo J.J. da Silva

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Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy

Lunde IG, Aronsen JM, Melleby AO, Strand ME, Skogestad J, Bendiksen BA, Ahmed MS, Sjaastad I, Attramadal H, Carlson CR, Christensen G.

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Tubulator: automated analysis of cardiomyocyte organelles and proteins in 3D

Frisk M, Norseng PA, Stenersen Espe EK, Louch WE

Tubulator: an automated approach to analysis of t-tubule and dyadic organization in cardiomyocytes

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A rhythmic collaboration: Key articles from IEMR for Norwegian Cardiologists caring for patients with PVCs

Premature ventricular complexes (PVC) is one of the most common ventricular arrhythmias encountered in clinical practice, and although most often benign, may cause debilitating symptoms, risk of left ventricular dysfunction, or life-threatening arrhythmias.

Using MR elastography to measure the hearts stiffness

Smith L, Skulberg V, Zhang L, Sjaastad I, Espe E (2022)

The effects of geometry on stiffness measurements in high-field magnetic resonance elastography: A study on rodent cardiac phantoms

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Signaling protein Syndecan-4 reveals new knowledge of the female heart

Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, Christensen G, Carlson CR (2022)

The female syndecan-4^-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels

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Prolonged β-Adrenergic stimulation and heart failure disperses ryanodine receptor clusters

Shen X, van den Brink J, Bergan-Dahl A, Kolstad TR, Norden ES, Hou Y, Laasmaa M, Aguilar-Sanchez Y, Quick AP, Espe EKS, Sjaastad I, Wehrens XHT, Edwards AG, Soeller C, Louch WE

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure.

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