Experimental Genetic Cardiology

Lunde group

We are a basic science cardiology group working on experimental models of heart failure, with particular focus on genetic heart failure.

Millions of patients worldwide suffer from heart failure. Heart failure is a chronic, deadly and costly syndrome, and we currently have no cure. Thus, research into its underlying molecular basis is necessary in order to understand the disease mechanisms, and thereby, design effective medical therapy to improve patient outcome.

Heart failure is often familial, suggesting a genetic cause.

We are a basic science cardiology group working on experimental models of heart failure, with particular focus on genetic heart failure. We are based at IEMR at OUH and UoO, and have extensive national and international research collaboration. We combine a range of molecular biology techniques and analyses, and aim at unravelling pathophysiological processes and mechanisms underlying heart failure.

In particular, we are interested in understanding the role of proteoglycans and titin in the heart.

Our experimental models and samples include heart biopsies from patients, mouse models with overexpression or knock-out of proteins, mouse models with human disease-causing mutations (e.g. familial HCM and DCM), heart tissue from mice and rats, and cultures of cardiac cells such as fibroblasts and cardiomyocytes.

Dr. Ida Gjervold Lunde is principal investigator and group leader at the Institute for Experimental Medical Research. In close collaborations with the Christensen, Tønnessen and Carlson Research Groups at IEMR.

Group members

Chloe Rixon

Doctoral Research Fellow

Karoline Bjarnesdatter Rypdal

Doctoral Research Fellow

Kine Andenæs

Doctoral Research Fellow

Latest publications

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Rypdal KB, Erusappan PM, Melleby AO, Seifert DE, Palmero S, Strand ME, Tønnessen T, Dahl CP, Almaas V, Hubmacher D, Apte SS, Christensen G, Lunde IG (2021)
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts
Sci Rep, 11 (1), 19757
PubMed 34611183 DOI 10.1038/s41598-021-99032-2
Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
PubMed 33509397 DOI 10.1016/j.jacc.2020.11.044
Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
PubMed 32000579 DOI 10.1161/JAHA.119.013518
Mohammadzadeh N, Melleby AO, Palmero S, Sjaastad I, Chakravarti S, Engebretsen KVT, Christensen G, Lunde IG, Tønnessen T (2020)
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload
Cardiology, 145 (3), 187-198
PubMed 31968347 DOI 10.1159/000505318
Tan CY, Wong JX, Chan PS, Tan H, Liao D, Chen W, Tan LW, Ackers-Johnson M, Wakimoto H, Seidman JG, Seidman CE, Lunde IG, Zhu F, Hu Q, Bian J, Wang JW, Foo RS, Jiang J (2019)
Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf
Circ Res, 125 (9), 834-846
PubMed 31495264 DOI 10.1161/CIRCRESAHA.119.314794
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Group news

Awards and prizes

Young Investigator Award

Awards and prizes

Norecopa’s 3R Prize