Per Kristian Lunde

Senior Researcher

Louch group

Email: p.k.lunde@medisin.uio.no
Phone: +47 230 16808

Education

2003 Dr. Philos. Medical faculty, University of Oslo, (Skeletal muscle dysfunction and calcium handling in heart failure)
1992 Cand. Scient. in Biochemistry, University of Oslo, (Quantification and characterisation of ryanodine sensitive calcium channel in skeletal muscle)
1980 Chemical engineer, Bergen college of engineering

Academic positions

2011-2012 Visiting researcher at Department of Physiology and Pharmacology, Karolinska institutet, Stockholm (Håkan Westerblads lab)
2008-present Senior research scientist, IEMR, OUS, Oslo, Norway
2005- Research scientist, IEMR, OUS, Oslo, Norway
2003- Post doc, IEMR, OUS, Oslo, Norway
1993- Biochemist, IEMR, OUS, Oslo, Norway

Funding, Employment information

Project manager for the “TRUST” project, a joint project between OUS and Norwegian school of sport sciences (NIH) (Skeletal muscle alterations after local muscle training in heart failure patients).

Founded by OUS, NIH, Norwegian heath association, The research council of Norway and University of Oslo

Awards

Director of OUS prize for eminent research (2005 and 2007),
and for early start of supervising on PhD level (2006).

Research area

Excercise physiology
Excitation contraction coupling
Heart failure

Latest publications

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Lunde PK, Manfra O, Støle TP, Lunde M, Martinsen M, Carlson CR, Louch WE (2023)
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 12 (19)
PubMed 37830576 DOI 10.3390/cells12192358

Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, Børstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM (2023)
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation, 147 (16), 1221-1236
PubMed 36876489 DOI 10.1161/CIRCULATIONAHA.121.054168

Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, Christensen G, Carlson CR (2022)
The female syndecan-4^-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
PubMed 36092718 DOI 10.3389/fcell.2022.908126

Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
PubMed 34814703 DOI 10.1161/CIRCRESAHA.120.317976

Mengeste AM, Lund J, Katare P, Ghobadi R, Bakke HG, Lunde PK, Eide L, Mahony GO, Göpel S, Peng XR, Kase ET, Thoresen GH, Rustan AC (2021)
The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells
Curr Res Pharmacol Drug Discov, 2, 100060
PubMed 34909682 DOI 10.1016/j.crphar.2021.100060

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