Hege Ugland

Email:  h.k.ugland@medisin.uio.no
Phone: +47 230 16 801

Education

– PhD, University of Oslo, Faculty of Medicine, Inst. of Basic Medical Sciences (2008)

– Cand. scient., University of Oslo, Faculty of Medicine, Inst. of Basic Medical Sciences (2002)

Publications

1. Follin-Arbelet V, Misund K, Naderi EH, Ugland H, Sundan A, Blomhoff HK. The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Sci Rep. 2015 Aug 26;5:13001. doi: 10.1038/srep13001.

2. Naderi EH, Skah S, Ugland H, Myklebost O, Sandnes DL, Torgersen ML, Josefsen D, Ruud E, Naderi S, Blomhoff HK. Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death. Mol Cancer. 2015 Jan 27;14:14. doi: 10.1186/s12943-014-0278-9.

3. Naderi EH, Ugland H, Diep PP, Josefsen D, Ruud E, Naderi S, Blomhoff HK. Selective inhibition of cell death in malignant vs normal B-cell precursors: implications for cAMP in development and treatment of BCP-ALL. Blood. 2013 Mar 7;121(10):1805-13. Epub 2013 Jan 8.

4. Ugland H, Naderi S, Brech A, Collas P, Blomhoff HK. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy. 2011 Oct;7(10):1199-211. Epub 2011 Oct 1.

5. Ugland H, Boquest AC, Naderi S, Collas P, Blomhoff HK. cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis. Mol Biol Cell. 2008 Dec;19(12):5082-92. Epub 2008 Sept 17.

6. Lahne HU*, Kloster MM, Lefdal S, Blomhoff HK, Naderi S. Degradation of cyclin D3 independent of Thr-283 phosphorylation. Oncogene. 2006 Apr 20;25(17):2468-76.

7. Naderi S, Gutzkow KB, Lahne HU*, Lefdal S, Ryves WJ, Harwood AJ, Blomhoff HK. cAMP-induced degradation of cyclin D3 through association with GSK-3beta. J Cell Sci. 2004 Aug 1;117(Pt 17):3769-83. Epub 2004 Jul 13.

8. Gutzkow KB, Lahne HU*, Naderi S, Torgersen KM, Skalhegg B, Koketsu M, Uehara Y, Blomhoff HK. Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation. Cell Signal. 2003 Sep;15(9):871-81.

Research area

• Cell signaling
• Heart failure